HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,5-Dimethyloxazolin-2-one → 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,5-Dimethyloxazolin-2-one | HCID 21464782 | — |
| Reactant | [4-(3,5-Dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484535 | — |
| Product | 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one | HCID 67380963 | 38.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 111 and using [4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (842 mg) described in Preparation Example 77 and 5,5-dimethyloxazolin-2-one (345 mg) described in Preparation Example 43, the title compound (312 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-07ef256e3a3949ccb1acdfa0994c9688 |
| Source note | uspto-grants-2013_01 |