HRID1804240

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58484543

未命名化合物

HCID58484601

未命名化合物

PRODUCTS

产物

HCID67380889

未命名化合物

收率 31.5%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 111 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (400 mg) described in Preparation Example 89 and (R)-4-methoxymethyloxazolidin-2-one (104 mg) described in Preparation Example 38, the title compound (138.6 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner as in Example 111
customdescribed in Preparation Example 38

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6d5234abae0948c4b8eb20e4fa230a5f
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08354401B2
来源说明: uspto-grants-2013_01

反应SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH:22]4[CH2:24][CH2:23]4)=[CH:20][C:19]([CH:25]4[CH2:27][CH2:26]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:28]([CH3:31])(=[O:30])=[O:29])[CH:3]=1.[CH3:32][O:33][CH2:34][C@@H:35]1[CH2:39][O:38][C:37](=[O:40])[NH:36]1>>[CH:22]1([C:21]2[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:36]5[C@H:35]([CH2:34][O:33][CH3:32])[CH2:39][O:38][C:37]5=[O:40])=[CH:3][C:4]=4[S:28]([CH3:31])(=[O:30])=[O:29])=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=[C:19]([CH:25]3[CH2:27][CH2:26]3)[CH:20]=2)[CH2:24][CH2:23]1