HCID 58484543, compound → HCID 67380889, compound

HRID 1804240Notes

Reaction equation

HRID 1804240 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH:22]4[CH2:24][CH2:23]4)=[CH:20][C:19]([CH:25]4[CH2:27][CH2:26]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:28]([CH3:31])(=[O:30])=[O:29])[CH:3]=1.[CH3:32][O:33][CH2:34][C@@H:35]1[CH2:39][O:38][C:37](=[O:40])[NH:36]1>>[CH:22]1([C:21]2[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:36]5[C@H:35]([CH2:34][O:33][CH3:32])[CH2:39][O:38][C:37]5=[O:40])=[CH:3][C:4]=4[S:28]([CH3:31])(=[O:30])=[O:29])=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=[C:19]([CH:25]3[CH2:27][CH2:26]3)[CH:20]=2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 58484543HCID 58484543, compoundHCID 58484601(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 67380889HCID 67380889, compoundYield 31.5%

Procedure

By reaction and treatment in the same manner as in Example 111 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (400 mg) described in Preparation Example 89 and (R)-4-methoxymethyloxazolidin-2-one (104 mg) described in Preparation Example 38, the title compound (138.6 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 111
  2. customdescribed in Preparation Example 38

Sources & evidence

ORD record
ord-6d5234abae0948c4b8eb20e4fa230a5f
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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