2-Oxazolidinone → 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804245Notes

Reaction equation

HRID 1804245 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[O:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:30]5[CH2:31][CH2:32][O:28][C:29]5=[O:33])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 673809953-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 84.9%

Procedure

By reaction and treatment in the same manner as in Example 149 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95, oxazolidin-2-one (104 mg), the title compound (367 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 149

Sources & evidence

ORD record
ord-285eeff9514d45e99f309e16e3c54254
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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