4,4-Dimethyl-1,3-oxazolidin-2-one → HCID 67381092, compound

HRID 1804247Notes

Reaction equation

HRID 1804247 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:28][C:29]1([CH3:35])[CH2:33][O:32][C:31](=[O:34])[NH:30]1>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:30]5[C:29]([CH3:35])([CH3:28])[CH2:33][O:32][C:31]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1413154,4-Dimethyl-1,3-oxazolidin-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 67381092HCID 67381092, compoundYield 43%

Procedure

By reaction and treatment in the same manner as in Example 110 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (473 mg) described in Preparation Example 95 and 4,4-dimethyloxazolidin-2-one (138 mg), the title compound (198 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 110

Sources & evidence

ORD record
ord-01c98c60773c4a6d91b0741555e83fde
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…