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HRID 1804248作成日：2026年10月25日

(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-ethyloxazolidin-2-one

https://huagongshe.com/reaction/1804248

反応式

関与物質

役割名称HCID仕込み量
反応物(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 641503—
反応物[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneHCID 58484841—
生成物(R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-ethyloxazolidin-2-oneHCID 6738070967.2%

反応手順

By reaction and treatment in the same manner as in Example 149 and using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (447 mg) described in Preparation Example 97 and (R)-4-ethyloxazolidin-2-one (138 mg) described in Preparation Example 26, the title compound (292 mg) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08354401B2
出典データセットuspto-grants-2013_01
ORD IDord-085d66809f9d46b0bdc1c459560ea78e
出典メモuspto-grants-2013_01