HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-methyloxazolidin-2-one → (S)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-5-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-methyloxazolidin-2-one | HCID 21794663 | — |
| Reactant | (4-Bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484761 | — |
| Product | (S)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}-5-methyloxazolidin-2-one | HCID 58484592 | 52.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2,6-difluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (615 mg) described in Preparation Example 60 and (S)-5-methyloxazolidin-2-one (243 mg) described in Preparation Example 42, the title compound (337 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-7d1b6795601e45c99923763d30ef9e0e |
| Source note | uspto-grants-2013_01 |