HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxazolidinone, 5,5-dimethyl- → 3-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5,5-dimethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxazolidinone, 5,5-dimethyl- | HCID 136892 | — |
| Reactant | (4-Bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484537 | — |
| Product | 3-{4-[4-(5-Ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5,5-dimethyloxazolidin-2-one | HCID 58484508 | 28.3% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-fluorophenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (1 g) described in Preparation Example 100 and 5,5-dimethyloxazolidin-2-one (437 mg) described in Preparation Example 43, the title compound (307 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-f47fcea58dde476d82872939584c067f |
| Source note | uspto-grants-2013_01 |