HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(3-chloro-5-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-Methyloxazolidin-2-one | HCID 2734858 | — |
| Reactant | (4-Bromo-2-fluorophenyl)[4-(3-chloro-5-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484756 | — |
| Product | (R)-3-{4-[4-(3-chloro-5-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-4-methyloxazolidin-2-one | HCID 58484813 | 95.5% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-fluorophenyl)[4-(3-chloro-5-methylpyridin-2-yl)piperazin-1-yl]methanone (626 mg) described in Preparation Example 110 and (R)-4-methyloxazolidin-2-one (227 mg) described in Preparation Example 25, the title compound (627 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0d443581bab64945a7ede42ab14f1b3a |
| Source note | uspto-grants-2013_01 |