2-Oxazolidinone → 3-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(2-oxopyrrolidin-1-yl)phenyl}oxazolidin-2-one

HRID 1804281Notes

Reaction equation

HRID 1804281 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([C:14]([N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:27]([CH3:28])=[CH:26][C:25]([CH3:29])=[CH:24][N:23]=3)[CH2:18][CH2:17]2)=[O:15])=[C:6]([N:8]2[CH2:12][CH2:11][CH2:10][C:9]2=[O:13])[CH:7]=1.[O:30]1[CH2:34][CH2:33][NH:32][C:31]1=[O:35]>>[CH3:28][C:27]1[C:22]([N:19]2[CH2:20][CH2:21][N:16]([C:14]([C:5]3[CH:4]=[CH:3][C:2]([N:32]4[CH2:33][CH2:34][O:30][C:31]4=[O:35])=[CH:7][C:6]=3[N:8]3[CH2:12][CH2:11][CH2:10][C:9]3=[O:13])=[O:15])[CH2:17][CH2:18]2)=[N:23][CH:24]=[C:25]([CH3:29])[CH:26]=1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 584846981-{5-Chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one

Product 1

HCID 584845533-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(2-oxopyrrolidin-1-yl)phenyl}oxazolidin-2-oneYield 10.4%

Procedure

By reaction and treatment in the same manner as in Example 201 and using 1-{5-chloro-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}pyrrolidin-2-one (206 mg) described in Preparation Example 121 and oxazolidin-2-one (43.5 mg), the title compound (24.1 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 201

Sources & evidence

ORD record
ord-c67f6d5f4f534bac8ae90bb6b05f3225
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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