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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804292Generated: October 26, 2026

(R)-4-Methyloxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl}-4-methyloxazolidin-2-one

https://huagongshe.com/reaction/1804292

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-4-Methyloxazolidin-2-oneHCID 2734858—
Reactant[4-Chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484702—
Product(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl}-4-methyloxazolidin-2-oneHCID 5848476731.6%

Reaction Steps

By reaction and treatment in the same manner as in Example 201 and using [4-chloro-2-(1,1-dioxo-1,2-thiazinan-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (218 mg) described in Preparation Example 128 and (R)-4-methyloxazolidin-2-one (47.6 mg) described in Preparation Example 25, the title compound (78.5 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-9cdb76e64a32434db677b132704c48e7
Source noteuspto-grants-2013_01