(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-hydroxymethyloxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one	HCID 16213752	—
Reactant	(4-Bromo-2-methylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484569	—
Product	(R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}-4-hydroxymethyloxazolidin-2-one	HCID 58484830	73.4%

Reaction Steps

By reaction and treatment in the same manner as in Example 19 and using (4-bromo-2-methylphenyl)[4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (350 mg) described in Preparation Example 129 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (289 mg), the title compound (280 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-fde82f45abe5430aaea46dd9effc5e15
Source note	uspto-grants-2013_01