反应详情

Over the course of 30 minutes, add a suspension of 1.28 g of KMnO4 in 15 ml of water dropwise to a solution of 0.5 g of the product of Example 2 dissolved in 25 ml of acetone. The reaction mixture is stirred at ambient temperature for 8 hours and then, following conventional extraction and treatment, the expected product is isolated by chromatography of the residue on silica gel (dichloromethane/methanol:98/2).

1. additionOver the course of 30 minutes, add
2. extractionextraction and treatment