(R)-4-Methyloxazolidin-2-one → HCID 58484786, compound

HRID 1804305Notes

Reaction equation

HRID 1804305 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([CH3:25])[CH:3]=1.[CH3:26][C@@H:27]1[CH2:31][O:30][C:29](=[O:32])[NH:28]1>>[CH3:26][C@@H:27]1[CH2:31][O:30][C:29](=[O:32])[N:28]1[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([CH3:25])[CH:3]=1

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484748HCID 58484748, compound

Product 1

HCID 58484786HCID 58484786, compoundYield 57.6%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methylphenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (172 mg) described in Preparation Example 132 and (R)-4-methyloxazolidin-2-one (65 mg) described in Preparation Example 25, the title compound (104 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1
  2. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-beef32c3aae04d89961488866e90b884
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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