HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxazolidinone → 3-{4-[4-(5-Cyano-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Reactant | 6-[4-(4-Bromo-2-methylbenzoyl)piperazin-1-yl]-5-methylnicotinonitrile | HCID 58484676 | — |
| Product | 3-{4-[4-(5-Cyano-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-methylphenyl}oxazolidin-2-one | HCID 58484773 | 23.4% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using 6-[4-(4-bromo-2-methylbenzoyl)piperazin-1-yl]-5-methylnicotinonitrile (210 mg) described in Preparation Example 133 and oxazolidin-2-one (69 mg), the title compound (50 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-9a934239a3f8433fac400788887c602c |
| Source note | uspto-grants-2013_01 |