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HRID1804309

反应详情

EQUATION

反应方程式

HRID 1804309 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H]1COC(=O)N1
HCID2734858

(R)-4-Methyloxazolidin-2-one

C4H7NO2

结构：Cc1cc(C#N)cnc1N1CCN(C(=O)c2ccc(Br)cc2F)CC1
HCID58484606

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C#N)cnc1N1CCN(C(=O)c2ccc(N3C(=O)OC[C@H]3C)cc2F)CC1
HCID58484664

未命名化合物

收率 76.6%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 1 and using 6-[4-(4-bromo-2-fluorobenzoyl)piperazin-1-yl]-5-methylnicotinonitrile (215 mg) described in Preparation Example 134 and (R)-4-methyloxazolidin-2-one (81 mg) described in Preparation Example 25, the title compound (173 mg) was obtained.

WORKUP

后处理

  1. customBy reaction and treatment in the same manner as in Example 1
  2. customdescribed in Preparation Example 25