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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804311Generated: November 3, 2026

6-(2-Oxooxazolidin-3-yl)nicotinic acid methyl ester → 3-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

https://huagongshe.com/reaction/1804311

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(2-Oxooxazolidin-3-yl)nicotinic acid methyl esterHCID 58484495—
Reactant1-(3,5-Dimethylpyridin-2-yl)piperazineHCID 58484496—
Product3-{5-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-oneHCID 5848456422.1%

Reaction Steps

By reaction and treatment in the same manner as in Example 63 and using 6-(2-oxooxazolidin-3-yl)nicotinic acid methyl ester (250 mg) described in Preparation Example 138 and 1-(3,5-dimethylpyridin-2-yl)piperazine (233 mg) described in Preparation Example 47, the title compound (95 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-2db7926ab3684175bcc0cd825e5a3237
Source noteuspto-grants-2013_01