2-Oxazolidinone → HCID 58484708, compound

HRID 1804314Notes

Reaction equation

Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH:22]4[CH2:24][CH2:23]4)=[CH:18][C:17]=3[CH3:25])[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[O:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH:22]1([C:19]2[CH:20]=[CH:21][C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:4]=[CH:3][C:2]([N:28]5[CH2:29][CH2:30][O:26][C:27]5=[O:31])=[N:7][CH:6]=4)=[O:9])[CH2:11][CH2:12]3)=[C:17]([CH3:25])[CH:18]=2)[CH2:24][CH2:23]1

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 58484486HCID 58484486, compound

Product 1

HCID 58484708HCID 58484708, compoundYield 77.7%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (6-bromopyridin-3-yl)[4-(4-cyclopropyl-2-methylphenyl)piperazin-1-yl]methanone (260 mg) described in Preparation Example 140 and oxazolidin-2-one (66 mg), the title compound (205 mg) was obtained.

Workup

customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-2712b9e8a40d4b45bfa7b639be35946b
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354401B2

Reaction notes

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