2-Oxazolidinone → HCID 58484494, compound

HRID 1804316Notes

Reaction equation

HRID 1804316 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:7]=[CH:6][C:5]=2[N:13]2[CH2:18][CH2:17][N:16]([C:19]([C:21]3[CH:22]=[N:23][C:24](F)=[CH:25][C:26]=3[CH3:27])=[O:20])[CH2:15][CH2:14]2)[CH2:3][CH2:2]1.[O:29]1[CH2:33][CH2:32][NH:31][C:30]1=[O:34]>>[CH:1]1([C:4]2[CH:9]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:7]=[CH:6][C:5]=2[N:13]2[CH2:18][CH2:17][N:16]([C:19]([C:21]3[C:26]([CH3:27])=[CH:25][C:24]([N:31]4[CH2:32][CH2:33][O:29][C:30]4=[O:34])=[N:23][CH:22]=3)=[O:20])[CH2:15][CH2:14]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484588HCID 58484588, compound

Product 1

HCID 58484494HCID 58484494, compoundYield 32.3%

Procedure

By reaction and treatment in the same manner as in Example 240 and using [4-(2,4-dicyclopropylphenyl)piperazin-1-yl](6-fluoro-4-methylpyridin-3-yl)methanone (500 mg) described in Preparation Example 142 and oxazolidin-2-one (459 mg), the title compound (190 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 240

Sources & evidence

ORD record
ord-3eb1207cef0e4dbe86c3b22f3ddbf1f6
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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