Methyl iodide → HCID 58484513, compound

HRID 1804319Notes

Reaction equation

HRID 1804319 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:32])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:19]=[CH:20][C:21]([N:24]5[C@H:28]([CH2:29][OH:30])[CH2:27][O:26][C:25]5=[O:31])=[N:22][CH:23]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:33]I>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:32])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:19]=[CH:20][C:21]([N:24]5[C@H:28]([CH2:29][O:30][CH3:33])[CH2:27][O:26][C:25]5=[O:31])=[N:22][CH:23]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484530HCID 58484530, compound

Product 1

HCID 58484513HCID 58484513, compound

Procedure

By reaction and treatment in the same manner as in Example 73 and using (R)-3-{5-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one (144 mg) described in Example 245 and methyl iodide (38 μL), the title compound (85 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 73

Sources & evidence

ORD record
ord-a31329ee89da49c8a5d097fd47dadcda
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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