HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxazolidinone → 3-{5-[4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Reactant | (6-Bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 86658776 | — |
| Product | 3-{5-[4-(3-Cyclopropyl-5-methylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one | HCID 58484524 | 56.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using (6-bromopyridin-3-yl)[4-(3-cyclopropyl-5-methylpyridin-2-yl)piperazin-1-yl]methanone (170 mg) described in Preparation Example 144 and oxazolidin-2-one (55 mg), the title compound (97 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-599a633bf4a647bd91c022a93a83f35e |
| Source note | uspto-grants-2013_01 |