HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-4-(Benzoyloxymethyl)oxazolidine-2-one | HCID 16213752 | — |
| Reactant | (6-Bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484777 | — |
| Product | (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one | HCID 58484584 | 53.4% |
Reaction Steps
By reaction and treatment in the same manner as in Example 19 and using (6-bromopyridin-3-yl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (880 mg) described in Preparation Example 112 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (650 mg), the title compound (510 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-bc202b8d070d4b64bb72ba8f1984f288 |
| Source note | uspto-grants-2013_01 |