Methyl iodide → (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-methoxymethyloxazolidin-2-one

HRID 1804325Notes

Reaction equation

HRID 1804325 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:22]=[CH:23][C:24]([N:27]5[C@H:31]([CH2:32][OH:33])[CH2:30][O:29][C:28]5=[O:34])=[N:25][CH:26]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[CH3:35]I>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:22]=[CH:23][C:24]([N:27]5[C@H:31]([CH2:32][O:33][CH3:35])[CH2:30][O:29][C:28]5=[O:34])=[N:25][CH:26]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484584(R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one

Product 1

HCID 58484834(R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-methoxymethyloxazolidin-2-one

Procedure

By reaction and treatment in the same manner as in Example 73 and using (R)-3-{5-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}-4-hydroxymethyloxazolidin-2-one (310 mg) described in Example 252 and methyl iodide (50 μL), the title compound (85 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 73

Sources & evidence

ORD record
ord-72b11eb38a1d440eba293c3c3a5e6e91
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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