(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-hydroxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one	HCID 16213752	—
Reactant	(6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484612	—
Product	(R)-4-hydroxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one	HCID 58484619	50%

Reaction Steps

By reaction and treatment in the same manner as in Example 19 and using (6-bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (540 mg) described in Preparation Example 146 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (474 mg), the title compound (295 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-133ebbc2403b415e97c03e3141c30d5f
Source note	uspto-grants-2013_01