Methyl iodide → (R)-4-methoxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

HRID 1804327Notes

Reaction equation

HRID 1804327 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:7][O:6][C:5](=[O:8])[N:4]1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][N:10]=1.[CH3:32]I>>[CH3:32][O:1][CH2:2][C@@H:3]1[CH2:7][O:6][C:5](=[O:8])[N:4]1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484619(R)-4-hydroxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

Product 1

HCID 58484656(R)-4-methoxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one

Procedure

By reaction and treatment in the same manner as in Example 73 and using (R)-4-hydroxymethyl-3-{5-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]pyridin-2-yl}oxazolidin-2-one (200 mg) described in Example 254 and methyl iodide (35 μL), the title compound (158 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 73

Sources & evidence

ORD record
ord-45a0a10efef04d4db088fb0a718352ef
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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