Pyridine, 2,3,5-trichloro- → HCID 58484764, compound

HRID 1804339Notes

Reaction equation

HRID 1804339 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1.Cl[C:25]1[C:30]([Cl:31])=[CH:29][C:28]([Cl:32])=[CH:27][N:26]=1>>[Cl:31][C:30]1[C:25]([N:21]2[CH2:20][CH2:19][N:18]([C:16]([C:13]3[CH:14]=[CH:15][C:10]([N:5]4[C@H:4]([CH2:3][O:2][CH3:1])[CH2:8][O:7][C:6]4=[O:9])=[CH:11][CH:12]=3)=[O:17])[CH2:23][CH2:22]2)=[N:26][CH:27]=[C:28]([Cl:32])[CH:29]=1

Participants

3

Reactant 2

HCID 27666Pyridine, 2,3,5-trichloro-HCID 58484555(R)-4-methoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one

Product 1

HCID 58484764HCID 58484764, compoundYield 66%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-methoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (473 mg) described in Preparation Example 165 and 2,3,5-trichloropyridine (405 mg), the title compound (455 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-5574cc382a614139b5dc945646b07043
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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