(4R)-4-ethyl-1,3-oxazolidin-2-one → HCID 58484807, compound

HRID 1804341Notes

Reaction equation

HRID 1804341 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH2:25]([C@@H:27]1[CH2:31][O:30][C:29](=[O:32])[NH:28]1)[CH3:26]>>[CH2:25]([C@@H:27]1[CH2:31][O:30][C:29](=[O:32])[N:28]1[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1)[CH3:26]

Participants

3

Reactant 2

HCID 641503(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 58484807HCID 58484807, compoundYield 77.2%

Procedure

By reaction and treatment in the same manner as in Example 149 and using (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (435 mg) described in Preparation Example 176 and (R)-4-ethyloxazolidin-2-one (138 mg) described in Preparation Example 26, the title compound (326 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 149
  2. customdescribed in Preparation Example 26

Sources & evidence

ORD record
ord-fd2eebd5bdcd44bea476949c2ea9440b
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…