Pyridine, 2,3,5-trichloro- → HCID 58484645, compound

HRID 1804344Notes

Reaction equation

HRID 1804344 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C@H:20]([CH2:21][O:22][CH3:23])[CH2:19][O:18][C:17]2=[O:24])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].Cl[C:26]1[C:31]([Cl:32])=[CH:30][C:29]([Cl:33])=[CH:28][N:27]=1>>[Cl:32][C:31]1[C:26]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:7]3[CH:6]=[CH:5][C:4]([N:16]4[C@H:20]([CH2:21][O:22][CH3:23])[CH2:19][O:18][C:17]4=[O:24])=[CH:3][C:2]=3[F:1])=[O:9])[CH2:11][CH2:12]2)=[N:27][CH:28]=[C:29]([Cl:33])[CH:30]=1

Participants

3

Reactant 2

HCID 27666Pyridine, 2,3,5-trichloro-HCID 58484850HCID 58484850, compound

Product 1

HCID 58484645HCID 58484645, compoundYield 59.5%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-3-[3-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one (875 mg) described in Preparation Example 158 and 2,3,5-trichloropyridine (945 mg), the title compound (746 mg) was obtained. MS(ESI)m/z:483(M+H)+.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-c5c8e3bc3f1b43138a40013727094936
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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