(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → HCID 58484576, compound

HRID 1804346Notes

Reaction equation

HRID 1804346 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24](I)=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.[O:28]=[C:29]1[NH:33][C@H:32]([CH2:34][O:35][C:36](=[O:43])[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH2:31][O:30]1>>[C:36]([O:35][CH2:34][C@@H:32]1[CH2:31][O:30][C:29](=[O:28])[N:33]1[C:24]1[CH:25]=[CH:26][C:21]([C:19]([N:16]2[CH2:17][CH2:18][N:13]([C:5]3[C:4]([CH:1]4[CH2:3][CH2:2]4)=[CH:9][C:8]([CH:10]4[CH2:11][CH2:12]4)=[CH:7][N:6]=3)[CH2:14][CH2:15]2)=[O:20])=[CH:22][CH:23]=1)(=[O:43])[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 16213752(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 58484688[4-(3,5-Dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 58484576HCID 58484576, compoundYield 90%

Procedure

By reaction and treatment in the same manner as in Example 149 and using [4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (1.42 g) described in Preparation Example 95 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (664 mg), the title compound (1.53 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 149

Sources & evidence

ORD record
ord-a12917e3711048adb35042d9a137138b
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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