Pyridine, 2,3,5-trichloro- → HCID 58484734, compound

HRID 1804349Notes

Reaction equation

HRID 1804349 reaction equation
[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[CH:13][CH:12]=1)[CH3:2].Cl[C:26]1[C:31]([Cl:32])=[CH:30][C:29]([Cl:33])=[CH:28][N:27]=1>>[Cl:32][C:31]1[C:26]([N:22]2[CH2:21][CH2:20][N:19]([C:17]([C:14]3[CH:15]=[CH:16][C:11]([N:6]4[C@H:5]([CH2:4][O:3][CH2:1][CH3:2])[CH2:9][O:8][C:7]4=[O:10])=[CH:12][CH:13]=3)=[O:18])[CH2:24][CH2:23]2)=[N:27][CH:28]=[C:29]([Cl:33])[CH:30]=1

Participants

3

Reactant 2

HCID 27666Pyridine, 2,3,5-trichloro-HCID 58484504HCID 58484504, compound

Product 1

HCID 58484734HCID 58484734, compoundYield 59.5%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-ethoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (1.39 g) described in Preparation Example 167 and 2,3,5-trichloropyridine (1.53 g), the title compound (1.19 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-c8b17ca0f790477aa4cfa4487b6185e7
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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