Pyridine, 2,3,5-trichloro- → HCID 58484679, compound

HRID 1804351Notes

Reaction equation

HRID 1804351 reaction equation
[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[C:13]([F:25])[CH:12]=1)[CH3:2].Cl[C:27]1[C:32]([Cl:33])=[CH:31][C:30]([Cl:34])=[CH:29][N:28]=1>>[Cl:33][C:32]1[C:27]([N:22]2[CH2:23][CH2:24][N:19]([C:17]([C:14]3[CH:15]=[CH:16][C:11]([N:6]4[C@H:5]([CH2:4][O:3][CH2:1][CH3:2])[CH2:9][O:8][C:7]4=[O:10])=[CH:12][C:13]=3[F:25])=[O:18])[CH2:20][CH2:21]2)=[N:28][CH:29]=[C:30]([Cl:34])[CH:31]=1

Participants

3

Reactant 2

HCID 27666Pyridine, 2,3,5-trichloro-HCID 58484589HCID 58484589, compound

Product 1

HCID 58484679HCID 58484679, compoundYield 66.6%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-ethoxymethyl-3-[3-fluoro-4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (1.23 g) described in Preparation Example 160 and 2,3,5-trichloropyridine (1.28 g), the title compound (1.16 g) was obtained. MS(ESI)m/z:497(M+H)+.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-a459bc72984b41c89d8a107fe200cfb3
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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