Pyridine, 2,3,5-trichloro- → HCID 58484641, compound

HRID 1804354Notes

Reaction equation

HRID 1804354 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([N:19]2[C@H:23]([CH2:24][O:25][CH3:26])[CH2:22][O:21][C:20]2=[O:27])[CH:8]=[CH:9][C:10]=1[C:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[O:12])(=[O:4])=[O:3].Cl[C:29]1[C:34]([Cl:35])=[CH:33][C:32]([Cl:36])=[CH:31][N:30]=1>>[Cl:35][C:34]1[C:29]([N:16]2[CH2:17][CH2:18][N:13]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([N:19]4[C@H:23]([CH2:24][O:25][CH3:26])[CH2:22][O:21][C:20]4=[O:27])=[CH:6][C:5]=3[S:2]([CH3:1])(=[O:3])=[O:4])=[O:12])[CH2:14][CH2:15]2)=[N:30][CH:31]=[C:32]([Cl:36])[CH:33]=1

Participants

3

Reactant 2

HCID 27666Pyridine, 2,3,5-trichloro-HCID 58484598HCID 58484598, compound

Product 1

HCID 58484641HCID 58484641, compoundYield 45.5%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-3-[3-methanesulfonyl-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one (1.19 g) described in Preparation Example 172 and 2,3,5-trichloropyridine (1.09 g), the title compound (740 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-c7d439b1b9274302b922afb436a0f2f4
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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