HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-benzoyloxymethyl-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-4-(Benzoyloxymethyl)oxazolidine-2-one | HCID 16213752 | — |
| Reactant | [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone | HCID 58484605 | — |
| Product | (R)-4-benzoyloxymethyl-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one | HCID 58484782 | 95.6% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 91 and using [4-(5-ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (2.18 g) described in Preparation Example 177 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.11 g), the title compound (2.53 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-9c1f11bbc358459ea0d0b9e22bbed94e |
| Source note | uspto-grants-2013_01 |