Methyl iodide → HCID 58484568, compound

HRID 1804363Notes

Reaction equation

HRID 1804363 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:31])[C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][OH:29])[CH2:26][O:25][C:24]4=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[CH3:32]I>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:31])[C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][O:29][CH3:32])[CH2:26][O:25][C:24]4=[O:30])=[CH:19][CH:18]=3)=[O:16])[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484617HCID 58484617, compound

Product 1

HCID 58484568HCID 58484568, compoundYield 88.4%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (637 mg) described in Example 307 and methyl iodide (255 mg), the title compound (582 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-edf2fc4443ea4eb191ca53cdda50b7c1
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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