HRID1804368

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID641503

(4R)-4-ethyl-1,3-oxazolidin-2-one

C5H9NO2

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(Br)cc2N2CCCS2(=O)=O)CC1

HCID58484554

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C4CC4)cc3C)CC2)c(N2CCCS2(=O)=O)c1

HCID58484781

(R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-4-ethyloxazolidin-2-one

C28H35N5O5S

收率 85.7%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 149 and using [4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (519 mg) described in Preparation Example 179 and (R)-4-ethyloxazolidin-2-one (138 mg) described in Preparation Example 26, the title compound (474 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner as in Example 149
customdescribed in Preparation Example 26

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-72586e7dae754504afa8bec6000e6658
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354401B2
来源说明: uspto-grants-2013_01

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH:23]4[CH2:25][CH2:24]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([N:26]2[CH2:30][CH2:29][CH2:28][S:27]2(=[O:32])=[O:31])[CH:3]=1.[CH2:33]([C@@H:35]1[CH2:39][O:38][C:37](=[O:40])[NH:36]1)[CH3:34]>>[CH:23]1([C:19]2[CH:20]=[C:21]([CH3:22])[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:36]5[C@H:35]([CH2:33][CH3:34])[CH2:39][O:38][C:37]5=[O:40])=[CH:3][C:4]=4[N:26]4[CH2:30][CH2:29][CH2:28][S:27]4(=[O:32])=[O:31])=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=2)[CH2:25][CH2:24]1