Methyl iodide → HCID 58484533, compound

HRID 1804371Notes

Reaction equation

HRID 1804371 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:39])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][OH:30])[CH2:27][O:26][C:25]5=[O:31])=[CH:20][C:19]=4[N:32]4[CH2:36][CH2:35][CH2:34][S:33]4(=[O:38])=[O:37])=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:40]I>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:39])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][O:30][CH3:40])[CH2:27][O:26][C:25]5=[O:31])=[CH:20][C:19]=4[N:32]4[CH2:36][CH2:35][CH2:34][S:33]4(=[O:37])=[O:38])=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484590HCID 58484590, compound

Product 1

HCID 58484533HCID 58484533, compoundYield 73.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-4-hydroxymethyloxazolidin-2-one (778 mg) described in Example 317 and methyl iodide (238 mg), the title compound (586 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-2682c79d5a414fed918bbb7a8509faee
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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