Methyl iodide → HCID 58484614, compound

HRID 1804378Notes

Reaction equation

HRID 1804378 reaction equation
[O:1]=[S:2]1(=[O:38])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[C:9]([N:30]2[C@H:34]([CH2:35][OH:36])[CH2:33][O:32][C:31]2=[O:37])[CH:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[C:26]([CH3:27])=[CH:25][C:24]([CH2:28][CH3:29])=[CH:23][N:22]=2)[CH2:17][CH2:16]1)=[O:14].[CH3:39]I>>[O:38]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[C:9]([N:30]2[C@H:34]([CH2:35][O:36][CH3:39])[CH2:33][O:32][C:31]2=[O:37])[CH:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:16][CH2:17][N:18]([C:21]2[C:26]([CH3:27])=[CH:25][C:24]([CH2:28][CH3:29])=[CH:23][N:22]=2)[CH2:19][CH2:20]1)=[O:14]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484798HCID 58484798, compound

Product 1

HCID 58484614HCID 58484614, compoundYield 73.3%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{3-(1,1-dioxoisothiazolidin-2-yl)-4-[4-(5-ethyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (761 mg) described in Example 327 and methyl iodide (238 mg), the title compound (572 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-72c938958d814a73812e4208ba6cbd93
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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