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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804381Generated: October 31, 2026

(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-benzoyloxymethyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804381

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 16213752—
Reactant[4-Bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484743—
Product(R)-4-benzoyloxymethyl-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-oneHCID 5848465895.9%

Reaction Steps

By reaction and treatment in the same manner as in Preparation Example 91 and using [4-bromo-2-(1,1-dioxoisothiazolidin-2-yl)phenyl][4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (1.72 g) described in Preparation Example 181 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (852 mg), the title compound (2.12 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-1f22d7f3b01c413193913a6e34988eab
Source noteuspto-grants-2013_01