Methyl iodide → HCID 58484814, compound

HRID 1804382Notes

Reaction equation

HRID 1804382 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C@H:27]([CH2:28][OH:29])[CH2:26][O:25][C:24]3=[O:30])=[CH:19][C:18]=2[N:31]2[CH2:35][CH2:34][CH2:33][S:32]2(=[O:37])=[O:36])=[O:16])[CH2:11][CH2:10]1.[CH3:38]I>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([C:15]([C:17]2[CH:22]=[CH:21][C:20]([N:23]3[C@H:27]([CH2:28][O:29][CH3:38])[CH2:26][O:25][C:24]3=[O:30])=[CH:19][C:18]=2[N:31]2[CH2:35][CH2:34][CH2:33][S:32]2(=[O:36])=[O:37])=[O:16])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484507HCID 58484507, compound

Product 1

HCID 58484814HCID 58484814, compoundYield 69.2%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}-4-hydroxymethyloxazolidin-2-one (687 mg) described in Example 332 and methyl iodide (221 mg), the title compound (488 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-52a9f9dfdc7c4461bf6029d5af37b5bf
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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