HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,5-Dimethyloxazolin-2-one → 3-{3,5-Difluoro-4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,5-Dimethyloxazolin-2-one | HCID 21464782 | — |
| Reactant | (4-Bromo-2,6-difluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484560 | — |
| Product | 3-{3,5-Difluoro-4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one | HCID 58484783 | 47.7% |
Reaction Steps
By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2,6-difluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone (594 mg) described in Preparation Example 185 and 5,5-dimethyloxazolin-2-one (207 mg) described in Preparation Example 43, the title compound (308 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-cd74f682f506459a9cbd281bb6604a06 |
| Source note | uspto-grants-2013_01 |