5,5-Dimethyloxazolin-2-one → 3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5,5-dimethyloxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	5,5-Dimethyloxazolin-2-one	HCID 21464782	—
Reactant	(4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484657	—
Product	3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}-5,5-dimethyloxazolidin-2-one	HCID 58484650	43.2%

Reaction Steps

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone (606 mg) described in Preparation Example 188 and 5,5-dimethyloxazolin-2-one (207 mg) described in Preparation Example 43, the title compound (284 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-9035ee756bfb496680220b9927b26c74
Source note	uspto-grants-2013_01