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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804392Generated: November 1, 2026

1,3-Oxazol-2(5H)-one → 3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804392

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Oxazol-2(5H)-oneHCID 14405094—
Reactant(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484548—
Product3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3,5-difluorophenyl}oxazolidin-2-oneHCID 5848465568.2%

Reaction Steps

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone (422 mg) described in Preparation Example 189 and oxazolin-2-one (104 mg), the title compound (292 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-49d0933da52746319e59a862425458b7
Source noteuspto-grants-2013_01