Methyl iodide → HCID 46190280, compound

HRID 1804397Notes

Reaction equation

HRID 1804397 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([N:25]2[C@H:29]([CH2:30][OH:31])[CH2:28][O:27][C:26]2=[O:32])[CH:6]=[CH:7][C:8]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10])#[N:2].[CH3:33]I>>[C:1]([C:3]1[CH:4]=[C:5]([N:25]2[C@H:29]([CH2:30][O:31][CH3:33])[CH2:28][O:27][C:26]2=[O:32])[CH:6]=[CH:7][C:8]=1[C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH3:24])=[CH:19][N:18]=2)[CH2:15][CH2:16]1)=[O:10])#[N:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484517HCID 58484517, compound

Product 1

HCID 46190280HCID 46190280, compoundYield 63.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{3-cyano-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (566 mg) described in Example 349 and methyl iodide (221 mg), the title compound (371 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-d0bb2b95945f4a999053798cce9fdbbc
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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