HRID1804399

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14405094

1,3-Oxazol-2(5H)-one

C3H3NO2

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(Br)cc2C#N)CC1

HCID58484573

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C2CC2)cnc1N1CCN(C(=O)c2ccc(N3CCOC3=O)cc2C#N)CC1

HCID58484502

未命名化合物

收率 81.6%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 110 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (425 mg) described in Preparation Example 194 and oxazolin-2-one (104 mg), the title compound (352 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner as in Example 110