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HRID 1804400作成日：2026年10月25日

(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-benzoyloxymethyl-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804400

反応式

関与物質

役割名称HCID仕込み量
反応物(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 16213752—
反応物5-Bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrileHCID 58484573—
生成物(R)-4-benzoyloxymethyl-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneHCID 4619028174.2%

反応手順

By reaction and treatment in the same manner as in Preparation Example 91 and using 5-bromo-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (1.58 g) described in Preparation Example 194 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (906 mg), the title compound (1.56 g) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08354401B2
出典データセットuspto-grants-2013_01
ORD IDord-bfcfc11f68954c50a0b36369aa87963f
出典メモuspto-grants-2013_01