Methyl iodide → HCID 58484695, compound

HRID 1804401Notes

Reaction equation

HRID 1804401 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([N:27]2[C@H:31]([CH2:32][OH:33])[CH2:30][O:29][C:28]2=[O:34])[CH:6]=[CH:7][C:8]=1[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH:24]3[CH2:26][CH2:25]3)=[CH:19][N:18]=2)[CH2:13][CH2:12]1)=[O:10])#[N:2].[CH3:35]I>>[C:1]([C:3]1[CH:4]=[C:5]([N:27]2[C@H:31]([CH2:32][O:33][CH3:35])[CH2:30][O:29][C:28]2=[O:34])[CH:6]=[CH:7][C:8]=1[C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[C:22]([CH3:23])=[CH:21][C:20]([CH:24]3[CH2:26][CH2:25]3)=[CH:19][N:18]=2)[CH2:15][CH2:16]1)=[O:10])#[N:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 58484604HCID 58484604, compound

Product 1

HCID 58484695HCID 58484695, compoundYield 54.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{3-cyano-4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (600 mg) described in Example 357 and methyl iodide (221 mg), the title compound (339 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-d25319a06c09408080c8609275832835
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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