2-Oxazolidinone → HCID 58484549, compound

HRID 1804402Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2].[O:35]1[CH2:39][CH2:38][NH:37][C:36]1=[O:40]>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:37]3[CH2:38][CH2:39][O:35][C:36]3=[O:40])[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 58484546HCID 58484546, compound

Product 1

HCID 58484549HCID 58484549, compoundYield 3.6%

Procedure

By reaction and treatment in the same manner as in Example 201 and using 1-acetyl-3-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (342 mg) described in Preparation Example 196 and oxazolidin-2-one (61.8 mg), the title compound (13.6 mg) was obtained.

Workup

customBy reaction and treatment in the same manner as in Example 201

Sources & evidence

ORD record: ord-dcfcf7238d6b41bf826cf5833e78d982
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354401B2

Reaction notes

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