(R)-4-Methyloxazolidin-2-one → HCID 58484697, compound

HRID 1804403Notes

Reaction equation

HRID 1804403 reaction equation
[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2].[CH3:35][C@@H:36]1[CH2:40][O:39][C:38](=[O:41])[NH:37]1>>[C:1]([N:4]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[C:13]([N:37]3[C@H:36]([CH3:35])[CH2:40][O:39][C:38]3=[O:41])[CH:12]=[CH:11][C:10]=2[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[C:29]([CH3:30])=[CH:28][C:27]([CH:31]4[CH2:33][CH2:32]4)=[CH:26][N:25]=3)[CH2:20][CH2:19]2)=[O:17])[C:5]1=[O:34])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 58484546HCID 58484546, compound

Product 1

HCID 58484697HCID 58484697, compoundYield 15.4%

Procedure

By reaction and treatment in the same manner as in Example 201 and using 1-acetyl-3-{5-chloro-2-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}imidazolidin-2-one (344 mg) described in Preparation Example 196 and (R)-4-methyloxazolidin-2-one (61.8 mg) described in Preparation Example 25, the title compound (51.3 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 201
  2. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-84f7951db97b41ee800a83ae2c82edf8
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…