1-(2,4-Xylyl)piperazine → HCID 58484763, compound

HRID 1804404Notes

Reaction equation

HRID 1804404 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14]1[CH:23]=[CH:22][C:17]([C:18](OC)=[O:19])=[CH:16][CH:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][C:25]1[CH:30]=[C:29]([CH3:31])[CH:28]=[CH:27][C:26]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14]1[CH:15]=[CH:16][C:17]([C:18]([N:35]2[CH2:36][CH2:37][N:32]([C:26]3[CH:27]=[CH:28][C:29]([CH3:31])=[CH:30][C:25]=3[CH3:24])[CH2:33][CH2:34]2)=[O:19])=[CH:22][CH:23]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 705441-(2,4-Xylyl)piperazineHCID 58484545HCID 58484545, compound

Product 1

HCID 58484763HCID 58484763, compoundYield 47.5%

Procedure

By reaction and treatment in the same manner as in Example 34 and using methyl (S)-4-(4-benzyl-2-oxooxazolidin-3-yl)benzoate (142 mg) described in Preparation Example 197 and 1-(2,4-dimethylphenyl)piperazine (87 mg), the title compound (101.8 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 34

Sources & evidence

ORD record
ord-ac5541cf62094a79aaf760ae545c0822
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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