4-Methylmorpholine → HCID 67381202, compound

Participants

Reaction Steps

To a mixture of 1-(2,4-dimethylphenyl)piperazin-2-one hydrochloride (1.2 g), 4-bromo-2-methanesulfonylbenzoic acid (1.4 g) and 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (DMT-MM) (2.1 g) were added chloroform (7.5 mL), methanol (7.5 mL) and N-methylmorpholine (550 μL), and the mixture was stirred at room temperature overnight. After evaporation of the solvent, the residue was purified by column chromatography (chloroform) to give 4-(4-bromo-2-methanesulfonylbenzoyl)-1-(2,4-dimethylphenyl)piperazin-2-one (2.24 g).

Provenance & Evidence