2-Oxazolidinone → HCID 58484779, compound

HRID 1804414Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[C@H:12]([CH3:24])[CH2:11]2)=[O:9])=[C:4]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:3]=1.[O:29]1[CH2:33][CH2:32][NH:31][C:30]1=[O:34]>>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:31]3[CH2:32][CH2:33][O:29][C:30]3=[O:34])=[CH:3][C:4]=2[S:25]([CH3:28])(=[O:27])=[O:26])=[O:9])[CH2:11][C@H:12]1[CH3:24]

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 67381409HCID 67381409, compound

Product 1

HCID 58484779HCID 58484779, compoundYield 39.6%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[(R)-4-(2,4-dimethylphenyl)-3-methylpiperazin-1-yl]methanone (814 mg) and oxazolidin-2-one (168 mg), the title compound (327 mg) was obtained.

Workup

customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record: ord-c4495aef737c4e98a3b16f9c7b9717b0
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08354401B2

Reaction notes

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